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Early Stroke Treatment Associated with Better Outcome Neurol 55:1649-1655, Marler,J.R.,et al, 2000 See this aricle in Pubmed Article Abstract If the NINDS rt-PA Stroke Trial treatment protocol is followed, this analysis suggests that patients treated 0 to 90 minutes from stroke onset with rt-PA have an increased odds of improvement at 24 hours and favorable 3-month outcome compare d to patients treated later than 90 minutes. No effect of OTT on intracranial hemorrhage was detected within the group treated with rt-PA, possibly due to low power.

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